The first dataset to provide allosteric drug design optimization process and evaluation indicators.
The first dataset showing the regulatory mechanisms of allosteric molecules on protein-protein interactions.
The dataset contains bitopic modulators that simultaneously regulate the orthosteric site and allosteric site.
The dataset provides all the human potential allosteric site predicted from experimental PDBs and Alphafold structures.
Allostery is pertinent to regulate a protein's functional activity induced by the action of an effector at a site distinct from the active site of biomolecules through alteration of conformation and/or dynamics. Allosteric Database (ASD) provides a versatile resource for structure, function, disease and related annotation for the well-established allosteric macromolecules and allosteric modulators since 1901, data in ASD is annually updated and freely served for biologists and medicinal chemists interested in allosteric regulation mechanism and allosteric drug discovery.
Allosteric Target Entries
Allosteric Modulator Entries
Allosteric Interactions
AlloSite Potential Sites
Allosteric PPI Regulations
Hit-to-Lead Records
Dualsteric Modulators
Covalent Modulators
The left map is powered by Clustrmaps, which shows the locations of visitors in real time.
ASD has been visited: times.
If you find ASD useful,please consider citing the references:
Allosteric regulation for PPI.
The first-ever dataset featuring hit-to-lead molecular optimization.
All human allosteric sites predicted from human proteome.
Predicting potential driver mutation in allosteric sites.
Predicting allosteric sites from orthosteric sites.
The first server for predicting allosteric driver mutations.
