DeepAlloDriver

Driver mutations can contribute to the initial and process of cancer. Allostery regulates protein function at an allosteric site away from the functional site. Thus, identifying the driver mutations in allosteric sites will be greatly benefit for deciphering the mechanism of cancer and developing allosteric drugs. Here, we provide a platform called DeepAlloDriver to predict the driver mutations by a deep-learning method, which exhibited >93% performance in both accuracy and precision. DeepAlloDriver will facilitate the revelation of the underlying mechanism during cancer progression and helps to prioritize cancer therapeutic targets.