欢迎访问分子设计课题组

分子设计课题组(Molecular Design Laboratory)创立于2009年9月,隶属于上海交通大学医学院细胞分化与凋亡教育部重点实验室。本课题组致力于药物化学、药物设计、生物信息学和化学生物学等学科的方法学发展,并将其应用于重要疾病的靶标识别、药物发现及调节机制探索等领域。特别是在别构药物发现领域,课题组发展了由别构蛋白解析、别构位点识别、别构激动剂/抑制剂筛选、别构结构优化到别构动态系统生物学研究的系统解决方案,以克服传统药物开发中的选择性及毒性问题,动态阐明疾病调节的分子机制。

新 闻

2022 新文章接收: Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells." has been accepted by Acta. Pharm. Sin. B.
2021 新文章接收: The paper titled "Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as novel targets for allosteric drug design." has been accepted by Nat. Commun.
2020 新文章接收: The paper titled "IDDB: a comprehensive resource featuring genes, variants, and characteristics associated with Infertility." has been accepted by Nucleic Acids Res.
2019 新文章接收: The paper titled "Unraveling allosteric landscapes of allosterome with ASD." has been accepted by Nucleic Acids Res.
2019 新文章接收: The paper titled "AlloDriver: a method for the identification and analysis of cancer driver targets." has been accepted by Nucleic Acids Res.
2018 新文章接收: The paper titled "Identification of a cellularly active SIRT6 allosteric activator" has been accepted by Nature Chemical Biology.